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I'm writing in hopes of maybe finding answers for ...

  • I'm writing in hopes of maybe finding answers for my 77 yr old grandma. All in a year's time she found out she has a type of lung cancer that spreads to other organs, which has since gotten in her bones. She started the Opdivo immunotherapy treatments and for the better part of the course of treatment, she's done great. She has recently for the better part of 3 months now been declining rapidly! After many hospital stays for "UTI's", sepsis, and lastly a rehab facility, the hospitalist at the rehab facility saw a big red flag on her combinations of methotrexate and xeljanz and immediately took her off of them both! Before these 2 medications, she use to get the Orencia infusions. For whatever reason she stopped those and has been on the methotrexate & xeljanz for over a year. After reading up on methotrexate toxicity and the major interaction warnings for the two, and reading numerous horror stories of just methotrexate toxicity in older patients, I'm really feeling like this maybe her problem! I'm just looking for any answer from anyone who may have had any serious side effects to either drug alone or especially in combination! Thank you

    Post created 2 months 2 weeks ago

Comments

  • I was on Remicade treatments

    I was on Remicade treatments and methotrexate for 16 years for RA.
    In the last year I started getting lumps and When I had a biopsy on one it ulcerated . It became open and infected. I was sent to Mayo and they found some lymphoma cells in blood around ulcer. They took me off methotrexate and told me to never take it again! Since then my blood has been find!

    2 months 2 weeks ago

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